Simvastatin-induced oral lichenoid lesion : a case report
Pattramon Tanasubsinn
Sakaeo Crown Prince Hospital, SakaeoKeywords :
oral lichenoid reaction, lichen planus, simvastatin
Abstract :
Drug-induced oral lichenoid reaction is a rare oral condition that has the same clinical and pathological characteristics with lichen planus, but it has a cause from systemic drug. Simvastatin is a widely used hypolipidemic drug in Thailand. There are a few studies about simvastatin-induced oral lichenoid reaction. This report presented a case of 66-year old female suffering from oral burning sensation and itching papules at arms and legs after starting simvastatin 10 mg/day for 6 months. The diagnosis of simvastatin-induced oral lichenoid reaction was established by the basis of the patient history, clinical and pathological features. Patient was referred to physician for simvastatin withdrawal and symptomatic management was carried out using 0.1% fluocinolone in ora-base and 0.1% betamethasone cream at the affected areas. Two months after simvastatin withdrawal, patient had complete resolution of skin lesions and partial resolution of oral lesions. However, oral lichenoid reaction has a malignant potential, so regular follow up is mandatory.
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